Antiplatelet agents and anaesthesia

New anticoagulants and antiplatelet agents in perioperative period: Recommendations and controversies!

Perioperative management of antiplatelet therapy.

Worldwide, cardiovascular events represent the major cause of morbidity and mortality. A key role in the pathogenesis of these events is played by platelets. Interventional procedures, with placement of coronary and vascular stents, often represent the preferred therapeutic strategy. Antiplatelet medications are considered first-line therapy in preventing cardiovascular thrombotic events. A wid...

Antiplatelet agents and perioperative bleeding.

PURPOSE To briefly review the risks, in patients presenting for surgery, associated with the available antiplatelet agents, and to present the principles that should guide the evaluation of these risks and how to manage them. METHODS A narrative review of the current medical literature in English and French. MAIN FINDINGS Antiplatelet agents [mainly acetylsalicylic acid, clopidogrel and gly...

Perioperative antiplatelet therapy: the case for continuing therapy in patients at risk of myocardial infarction.

Recent clinical data show that the risk of coronary thrombosis after antiplatelet drugs withdrawal is much higher than that of surgical bleeding if they are continued. In secondary prevention, aspirin is a lifelong therapy and should never be stopped. Clopidogrel is regarded as mandatory until the coronary stents are fully endothelialized, which takes 3 months for bare metal stents, but up to 1...

Synthesis of N-arylmethyl Substituted Indole Derivatives as New Antiplatelet Aggregation Agents

A number of N-arylmethyl substituted indole derivatives have been synthesized and their effectiveness against ADP and arachidonic acid induced platelet aggregation in human plasma was determined. The desired compounds were synthesized by reacting the appropriate aniline derivative with isatin (or substituted isatin) to form the corresponding imine structures. The so formed compound was then act...